Epidemiological Profile of Asymptomatic Bacteriuria in Pregnant Women at the Mother and Child University Hospital Center of N’Djamena: Associated Risk Factors and Antibiotic Resistance
Keywords:
MHD, Free convective, Inclination, Poiseuille flow, Runge-Kutta method., Climate Change, social crisis, collapse, Asymptomatic bacteriuria, pregnant woman, antibiotic resistance, risk factor,Abstract
Asymptomatic bacteriuria in pregnant women is a bacterial urinary tract infection without any of the typical symptoms that are associated with a urinary tract infection whose urine culture meets the criteria for urinary tract infection corresponding to a colony count greater than 100 x 10 6 forming units of bacteria per liter. The objective of this work was to determine the prevalence of asymptomatic bacteriuria in pregnant women and to evaluate the effectiveness of antibiotics against isolated bacteria to better care for pregnant women. This is a prospective and analytical study based on the cytobacteriological xamination of urine including 185 pregnant women who came to the prenatal consultation service of the University Hospital for Mother and Child, from January 2022 to December 2022. The isolation, identification and sensitivity tests of the isolated bacteria to antibiotics were carried out under standard clinical microbiology conditions.
Among 185 pregnant women who were screened by urine cytobacteriological examination, 91 (49.18%) cases were positive. The average age of the patients was 27.08 years with extremes ranging from 16 to
39 years. The age group of 22 to 27 years old was predominant with a rate of 35.16% followed by that of 28 to 33 years old (31.87%). The bacterial strains isolated were Escherichia coli (37.63%), Streptococcus agalactiae (23.65%), Klebsiella pneumoniae (4.30%), Mycoplasma hominis (4.30%), Ureaplasma spp (3.22%) and Pseudomonas aeruginosa (2.15%). The antecedents most frequently associated with asymptomatic bacteriuria were urinary infections (43.96%) followed by 13.19% cesarean section.
The antibiogram of bacterial agents showed an average resistance of 47.43% of Escherichia coli to beta-lactams. 100% of Staphylococcus aureus were sensitive to fusidic acid and 90.91% resistant to vancomycin. Ureaplasma spp and Mycoplasma homonis developed an average resistance of 50% to fluoroquinolones and 25% to (lincosamides, macrolides and tetracycline). This study not only revealed the high level and frequency of bacteria associated with urinary infections in pregnant women, but also showed a strong resistance of bacteria and especially Escherichia coli to aminopenicillins and a high sensitivity of Staphylococcus aureus to acid. fusidic.
References
Haute Autorité de santé, Société de pathologie infectieuse de langue française (2016) Femme enceinte : colonisation urinaire et cystite. https://www.has-sante.fr/portail/upload/docs/application/pdf/2016-11/v1-fm_cystitefemme_enceinte_cd151116.pdf
(2010) Sexually transmitted diseases. Bacterial vaginosis. http://www.cdc.gov/std/bv/default.htm
(2016) CRAT : Centre de référence sur les agents tératogènes. https://www.lecrat.fr/
F. Caron, T. Galperine, C Flateau, R. Azria, S. Bonacorsi, F Bruyer, et al (2018) Practice guidelines for the management of adult community-acquired urinary tract infections. 48(5), 327-358. https://doi.org/10.1016/j.medmal.2018.03.005
D.S. Ipe, L. Sundac, W.H.J. Benjamin, K.H. Moore, G.C. Ulett (2013) Asymptomatic bacteriuria: prevalence rates of causal microorganisms, etiology of infection indifferent patient population and recent advances in molecular detection. 34(1), 1-10.
V.M. Allen, M.H. Yudin (2012) Management of group B streptococcal bacteriuria in pregnancy. 34(5), 482-486.
T. Cai, S. Mazzoli, N. Mondaini, F. Meacci, G. Nesi, C. D'Elia, et al (2012) The role of asymptomatic bacteriuria in young women with recurrent urinary tract infections: to treat or not to treat?. 55(6), 771.
Aireen Wingert, Jennifer Pillay, Meghan Sébastienski, Michelle Gates, Robin Pierre-Plume, Kassi Rasage, Ben Vandermeer, Lisa Hartling (2019) Bactériurie asymptomatique pendant la grossesse : revues systématiques de l'efficacité du dépistage et du traitement et des préférences des patientes. 9(3), 1-10.
D.O. Awonuga, H.O. Dada-Adegbola, A.O. Fawole, F.A. Olola, O.M. Awonuga, H.O. Onimisi-Smith (2011) Asymptomatic bacteriuria among an Obstetric population in Ibadan. 30(2), 89-93.
H.Z. Hamdan, A.H.M. Ziad, S.K. Ali, Adam Ishag (2011) Epidemiology of urinary tract infections and antibiotics sensitivity among pregnant women at Khartoum North Hospital. 30(2), 1-5.
F.M. Smaill, J.C. Vazquez (2015) Antibiotics for asymptomatic bacteriuria in pregnancy. 8. https://doi.org/10.1002/14651858.CD000490.pub3
N.S.M. Hailaji, M.L. Salem, S.M. Ghaber (2016) La sensibilité aux antibiotiques des bactéries uropathogènes dans la ville de Nouakchott-Mauritanie. 26(6), 346-375.
F. Jehl (2013) Recommendations. (n.19), 133-142.
P.A. Wayne (2016) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 35(n. 2), PMo7-A10.
M. Jalali, M. Shamsi, N. Roozbehani, K. Kabir (2014) Prevalence of Urinary Infection and some Factors Affected in Pregnant women in Iran Karaj City 2013. 20(7), 781-785.
N. Kalla, O. Mansouri, A. Ouffai, H. Mahdjoub, R. Ait Hamouda, S. Tebba (2018) Les facteurs de risquer d'infection urinaire BMR chez la femme enceinte : étude analytique. 48(4), S46-S47.
N. Boulakehal, A. Lezzar, A. Segueni (2016) Bactériurie asymptomatique de la femme enceinte. 24(1), 17-22.
A.P. Glaser, A.J. Schaeffer (2015) Urinary tract infection and bacteriuria in pregnancy. 42(4), 547-560.
E. Taale, S.Sanou, I. Sangare, A.D.Abdekerim, A.Mbatna, C. Sirima, Savadogo (2016) Urinary tract infection among pregnant women at Bobo-dioulasso: Epidemiological and bacteriological aspects. 8(3), 1132-1145.
K. Frederickson, D. Buckland, R Sayal (2017) Patient preferences in considering asymptomatic bacteriuria screening and treatment outcomes. http://canadiantaskforce.ca/guidelines/published-guidelines/asymptomatic-bacteriuria/
R. Gauzit, B. Castan, E. Bonnet, J.P. Bru, R. Cohen, S Diamantis (2021) Anti-infectious treatment duration: The SPILF and GPIP French guidelines and recommendations. 51(2), 114-139. https://doi.org/10.1016/j.idnow.2020.12.001
B.E. Olsen, S.G. Hinderakers, R.T. Lie, P. Gasheka, A. Baerhum, p. Bergsjo, G. Kvale (2010) The diagnosis of urinary tract infection among pregnant women in rural Tanzania, prevalence and correspondence between different diagnostic methods. 79(9), 729-736.
A. ALemu, F. Moges, Y. B. Shiferaw (2012) Bacterial profile and drug susceptibility pattern of urinary tract infection in pregnant women at University of Gondar Teaching Hospital, Northwest Ethiopia. 5(197), 1-7.
Zariane Djimasse Gbaguidi, Candide PY Bankole, Honoré et al (2015) Analyse Situationnelle des bactéries d'infection urinaires chez les femmes enceintes à Porto-Novo. 43.
Aida Bahloul (2017) Diagnosie et antibiothérapie des infections urinaires chez la femme enceinte. http://localhost:8080/jspui/handle/123456789/2074
B. Wullt, C. Svanborg (2016) Deliberate Establishment of asymptomatic bacteriuria-a novel strategy to prevent recurrent UTI. 5(3), 52.
Jingjuan Song, Xuanlan Wu, Yingying Kong, Hong Jin, Ting Yang, Xinyou Xie, Jun Zhang (2022) Prevalence and antibiotic resistance of Ureaplasma species and Mycoplasma hominis in Hangzhou, China, from 2013 to 2019. 13(982429), 1-8. https://doi.org/10.3389/fmicb.2022.982429
I. Guindo, M. Ag Baraïka, M. S. Sangaré, M. Sima, S. Ongoiba, S. Dao, F. Bougoudogo (2022) Profil de résistance aux antibiotiques de Mycoplasma hominis et Ureaplasma urealyticum identifiés chez les femmes à Bamako, Mali. 17(1), 32-37.
Ndoutamia Guelmbaye Ndoutamia, Henry Fissou Yandai, Nadlaou Bessimbaye (2015) Antimicrobial resistance in extended spectrum beta-lactamases (ESBL)-producing Escherichia coli isolated from human urinary tract infections in N'djamena. (11), 776-780.
Henry Fissou Yandai, Ndoutamia Guelmbaye, Nadlaou Bessimbaye, Nicolas Barro (2019) Prevalence and resistance profile of Ecsherichia coli and Klebsiella pneumoniae isolated from urinary tract infection in N'djamena, Tchad. 13(4), 2065-2073.
(2014) Diagnostic et antibiothérapie des infections urinaires bactériennes communautaires de l'adulte. http://www.infectiologie.com/
M. Widmer, A. M. Gulmezoglu, L. Mignini, A. Roganti (2015) Duration of treatment for asymptomatic bacteriuria during pregnancy (Reviews). 11(2015), 1-30.
R.A. Hashem, A.S. Yassin, H.H. Zedan, M.A. Amin (2013) Fluoroquinolone resistant mechanisms in methicillin-resistant Staphylococcus aureus clinical isolates in Cairo, Egypt. 7(11), 796–803. https://doi.org/10.3855/jidc.310554
Asnakew Abebe, Godana Birhanu (2023) Methicillin Resistant Staphylococcus aureus: Molecular Mechanisms Underlying Drug Resistance Development and Novel Strategies to Combat. 16, 7641-7662.
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